Nonlytic exocytosis of Cryptococcus neoformans from neutrophils in the brain vasculature
Identifieur interne : 000587 ( Main/Exploration ); précédent : 000586; suivant : 000588Nonlytic exocytosis of Cryptococcus neoformans from neutrophils in the brain vasculature
Auteurs : Xiaofan Yang [République populaire de Chine] ; Huijuan Wang [République populaire de Chine] ; Fan Hu [République populaire de Chine] ; Xichen Chen [République populaire de Chine] ; Mingshun Zhang [République populaire de Chine]Source :
- Cell Communication and Signaling : CCS [ 1478-811X ] ; 2019.
Abstract
A blood-brain barrier (BBB) in vitro model was established. The interactions between neutrophils adhering to brain endothelial cells and fungi were observed under a live cell imaging microscope. A flow cytometry assay was developed to explore the mechanisms. Immunofluorescence staining of brain tissues was utilized to validate
Using real-time imaging, we observed that neutrophils adhered to a monolayer of mouse brain endothelial cells could expel ingested
These results highlight a novel function by which neutrophils extrude
The online version of this article (10.1186/s12964-019-0429-0) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12964-019-0429-0
PubMed: 31500648
PubMed Central: 6734394
Affiliations:
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nonlytic exocytosis of <italic>Cryptococcus neoformans</italic>
from neutrophils in the brain vasculature</title>
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<author><name sortKey="Wang, Huijuan" sort="Wang, Huijuan" uniqKey="Wang H" first="Huijuan" last="Wang">Huijuan Wang</name>
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<series><title level="j">Cell Communication and Signaling : CCS</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1"><italic>Cryptococcus neoformans</italic>
(<italic>C. neoformans</italic>
) is an encapsulated budding yeast that causes life-threatening meningoencephalitis in immunocompromised individuals, especially those with acquired immunodeficiency syndrome (AIDS). To cause meningoencephalitis, <italic>C. neoformans</italic>
circulating in the bloodstream must first be arrested in the brain microvasculature. Neutrophils, the most abundant phagocytes in the bloodstream and the first leukocytes to be recruited to an infection site, can ingest <italic>C. neoformans</italic>
. Little is known about how neutrophils interact with arrested fungal cells in the brain microvasculature.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">A blood-brain barrier (BBB) in vitro model was established. The interactions between neutrophils adhering to brain endothelial cells and fungi were observed under a live cell imaging microscope. A flow cytometry assay was developed to explore the mechanisms. Immunofluorescence staining of brain tissues was utilized to validate <italic>the</italic>
in vitro phenomena.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">Using real-time imaging, we observed that neutrophils adhered to a monolayer of mouse brain endothelial cells could expel ingested <italic>C. neoformans</italic>
without lysis of the neutrophils or fungi in vitro, demonstrating nonlytic exocytosis of fungal cells from neutrophils. Furthermore, nonlytic exocytosis of <italic>C. neoformans</italic>
from neutrophils was influenced by either the fungus (capsule and viability) or the neutrophil (phagosomal pH and actin polymerization). Moreover, nonlytic exocytosis of <italic>C. neoformans</italic>
from neutrophils was recorded in brain tissue.</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">These results highlight a novel function by which neutrophils extrude <italic>C. neoformans</italic>
in the brain vasculature.</p>
</sec>
<sec><title>Graphical abstract</title>
<p id="Par5"><graphic position="anchor" xlink:href="12964_2019_429_Figa_HTML" id="MO1"></graphic>
</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (10.1186/s12964-019-0429-0) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Xiaofan" sort="Yang, Xiaofan" uniqKey="Yang X" first="Xiaofan" last="Yang">Xiaofan Yang</name>
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<name sortKey="Chen, Xichen" sort="Chen, Xichen" uniqKey="Chen X" first="Xichen" last="Chen">Xichen Chen</name>
<name sortKey="Hu, Fan" sort="Hu, Fan" uniqKey="Hu F" first="Fan" last="Hu">Fan Hu</name>
<name sortKey="Wang, Huijuan" sort="Wang, Huijuan" uniqKey="Wang H" first="Huijuan" last="Wang">Huijuan Wang</name>
<name sortKey="Zhang, Mingshun" sort="Zhang, Mingshun" uniqKey="Zhang M" first="Mingshun" last="Zhang">Mingshun Zhang</name>
<name sortKey="Zhang, Mingshun" sort="Zhang, Mingshun" uniqKey="Zhang M" first="Mingshun" last="Zhang">Mingshun Zhang</name>
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